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Realised by ALMS™
developer of the AIDS-HIV Reference project
Abstract No.: L4
Speaker: Adriano Aguzzi
Session: Plenary Lecture L4
Presentation date: Thu, Aug 31, 2006
Presentation time: 09:00 – 09:50

Recent Progress in Prion Biology

Adriano Aguzzi1

1 University Hospital of Zurich, Zurich, Switzerland

Correspondence address: Adriano Aguzzi, University Hospital of Zurich, Department of Pathology, Institute of Neuropathology, Schmelzbergstrasse 12, Zurich, 8091 Switzerland.

Web site: http://www.neuropathologie.usz.ch/english/

Keywords: Protein.

Transmissible spongiform encephalopathies (TSE) are fatal neurodegenerative diseases of humans and animals. The underlying infectious agent, the prion, accumulates not only in the central nervous system (CNS) but also in secondary lymphoid organs. I will revisit the role of the immune system in peripheral prion pathogenesis, while focusing on the mechanisms by which extraneural and extralymphatic prion infectivity develops. Interestingly, the same pro-inflammatory cytokines and homeostatic chemokines that are involved in lymphoid neogenesis and compartmentalization of immune cells appear to represent the crucial molecular switches responsible for the establishment of extraneural prion reservoirs.